Bazin's hydroa vacciniforme
A rare photodermatitis with vesicular eruption and vacciniform scarring.
Hydroa vacciniforme is a chronic skin disorder triggered by sunlight, first documented by Pierre-Antoine-Ernest Bazin in 1862. It usually begins in childhood, appearing as small blisters on sun-exposed areas like the face and hands. These blisters later form pitted scars. The condition is very rare.
Quick Facts
- First described
- 1862
- Described by
- Pierre-Antoine-Ernest Bazin
- Prevalence
- 0.34 cases per 100,000 population
- Average age of onset
- 7.9 years
Facts from the source article.
Did You Know?
- Hydroa vacciniforme is classified as one of the Epstein–Barr virus–associated lymphoproliferative diseases.
- Histology commonly shows dense perivascular lymphocytic infiltration with reticulated degeneration of the epidermis.
- A study detected EBV positive T-cells in the perivascular infiltration on biopsy in 28 of 29 patients tested.
Natural history
In many children hydroa vacciniforme regresses spontaneously by early adulthood. In a study of 29 patients, 11 of 18 with definite or probable HV were available for follow-up and all were alive without progression of their symptoms, though some had recurrent eruptions. Among 11 severe patients, 6 had evidence of chronic EBV infection, 5 had hypersensitivity to mosquito bites, 4 had virus-associated hemophagocytic syndrome, and 6 had natural killer cell lymphocytosis in the peripheral blood.
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