Broad beta disease
A lipid disorder causing palm xanthomas and early heart disease.
Last updated
Broad beta disease, also known as familial dysbetalipoproteinemia or type III hyperlipoproteinemia, is characterized by elevated total cholesterol and triglycerides with decreased HDL. It is notable for causing xanthoma striatum palmare and tuberoeruptive xanthomas, and for leading to premature atherosclerosis.
Quick Facts
- Signs
- xanthoma striatum palmare, tuberoeruptive xanthomas
- Genetic factor
- mutation in apolipoprotein E (ApoE)
- Risk genotype
- two copies of the ApoE2 gene
- Affected lipoproteins
- chylomicrons
- IDL
- VLDL (remnants)
Facts from the source article.
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Sources
Compiled from Wikipedia and the sources listed below. Text from Wikipedia is available under CC BY-SA 4.0; this entry is adapted from it.
- Wikipedia: Familial dysbetalipoproteinemia (CC BY-SA 4.0).
- Word definitions: the Codexery glossary, each quoted from its Wikipedia article.
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