Convergent synthesis
A strategy to improve efficiency in multistep organic synthesis.
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The process involves first creating several separate fragments of a target complex molecule, then joining those fragments together in a later step to yield the final product.[1]
Last updated 2026-09-30 from the source article.
Quick Facts
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Facts from the source article.
Key facts and history
In linear synthesis the overall yield quickly drops with each reaction step.[1] An example of its use in total synthesis is the final step towards the compound biyouyanagin A.[2] That final step was a photochemicalcycloaddition.[2] The total synthesis and revised structure of biyouyanagin A was published in 2007 by K. C. Nicolaou, David Šarlah, and David Murray Shaw.[3]
Dendrimer synthesis provides an example of convergent synthesis, where pre-formed branched units are attached to a central core.[2] Using chemical ligation, a convergent approach enables the production of proteins containing up to 300 amino acids.[2]
What the research sources say
The 2007 paper by Nicolaou, Šarlah, and Shaw describes the total synthesis and revised structure of biyouyanagin A.[3] That paper has been cited by 113 works.[3]
References
- Wikipedia, "Convergent synthesis" (CC BY-SA 4.0), which cites: Organic Synthesis, 3rd Ed. 2010 Michael Smith (original not read by us) en.wikipedia.org
- Wikipedia, "Convergent synthesis" (CC BY-SA 4.0), which cites: Convergent Synthesis of Internally Branched PAMAM Dendrimers Michael Pittelkow, Jrn B. Christensen Org. Lett., 7 (7), 1295–1298, 2005; Total Synthesis and Revised Structure of Biyouyanagin A K. C. Nicolaou, David Sarlah, and David M. Shaw Angew. Chem. Int. Ed. 2007, 46, 4708–4711 (we also read that source) en.wikipedia.org
- K. C. Nicolaou, "Total Synthesis and Revised Structure of Biyouyanagin A", Angewandte Chemie International Edition (2007), doi:10.1002/anie.200701552. OpenAlex metadata CC0; paper not read. doi.org
Each numbered sentence above was checked against the source it cites before publication. Sentences citing Wikipedia adapt text from the English Wikipedia article Convergent synthesis (contributors), used under CC BY-SA 4.0; this entry is available under the same licence. Other sources were used for facts only; no text or images are copied from them.
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Sources
Compiled from Wikipedia and the sources listed below. Text from Wikipedia is available under CC BY-SA 4.0; this entry is adapted from it.
- Wikipedia: Convergent synthesis (CC BY-SA 4.0).
- Word definitions: the Codexery glossary, each quoted from its Wikipedia article.
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