Divergent synthesis
A strategy to generate diverse chemical libraries efficiently.
Last updated
Blaboo10 · CC BY-SA 3.0
A method for rapidly generating libraries of molecules, diversity-oriented synthesis prioritizes variation in molecular skeletons.[1] By treating a single initial molecule with various reagents, distinct carbon frameworks can be produced within a single synthetic step.[1]
Quick Facts
- Field
- Chemistry
- Known for
- Strategy to improve efficiency of chemical synthesis by generating libraries of compounds
- Type
- Chemical synthesis strategy
Facts from the source article.
Key facts and history
The strategy is also called diversity oriented synthesis or DOS.[1] This starting compound can then be transformed via multiple reaction paths.[1] One path uses cycloisomerization with Pd(PPh3)2(OAc)2.[1] Another path uses enyne metathesis with a Hoveyda–Grubbs catalyst.[1]
Martin D. Burke and Stuart L. Schreiber published a planning strategy for diversity-oriented synthesis in 2003.[2] Naoya Kumagai, Giovanni Muncipinto, and Stuart L. Schreiber published a short synthesis of skeletally and stereochemically diverse small molecules in 2006.[3]
What the research sources say
The 2003 paper by Burke and Schreiber has been cited by 1493 works.[2] The 2006 paper by Kumagai, Muncipinto, and Schreiber has been cited by 168 works.[3]
References
- Wikipedia, "Divergent synthesis" (CC BY-SA 4.0), which cites: Burke, "A Planning Strategy for Diversity-Oriented Synthesis", Angewandte Chemie International Edition, 2004, p. 46–58; Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions Naoya Kumagai, Gi; Path b to 3: cycloisomerization with Pd(PPh<sub>3</sub>)<sub>2</sub>(OAc)<sub>2</sub>. Path c to 4: enyne metathesis with Hoveyda–Grubbs catalyst. Path d to 5: (we also read that source) en.wikipedia.org
- Martin D. Burke, "A Planning Strategy for Diversity‐Oriented Synthesis", Angewandte Chemie International Edition (2003), doi:10.1002/anie.200300626. OpenAlex metadata CC0; paper not read. doi.org
- Naoya Kumagai, "Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions", Angewandte Chemie International Edition (2006), doi:10.1002/anie.200600497. OpenAlex metadata CC0; paper not read. doi.org
Each numbered sentence above was checked against the source it cites before publication. Sentences citing Wikipedia adapt text from the English Wikipedia article Divergent synthesis (contributors), used under CC BY-SA 4.0; this entry is available under the same licence. Other sources were used for facts only; no text or images are copied from them.
More in Organic Chemistry And Reaction Mechanisms
Sources
Compiled from Wikipedia and the sources listed below. Text from Wikipedia is available under CC BY-SA 4.0; this entry is adapted from it.
- Wikipedia: Divergent synthesis (CC BY-SA 4.0).
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