Anti-Spiral

The Anti-Spiral is not an alien race but a single entity formed from the collective consciousness of a race that once faced the Spiral Nemesis and transformed itself into the Anti-Spiral. It emerges in the second half of the series, using Nia as their messenger after taking control of her—she was originally created by Lordgenome as his daughter, not by the Anti-Spiral. They send the Moon on a collision course with Earth to wipe out the planet's life and prevent humans from evolving to the extent they will risk destroying the universe in a cataclysmic event called the Spiral Nemesis.

Lordgenome, who became a bio-computer by his own choice after his defeat (not integrated by the Anti-Spiral), reveals he was once part of an intergalactic army of warriors who failed to stop the Anti-Spiral and forced mankind underground to protect them. The Moon seen in the first half of the series was not the real Moon; it was Lordgenome's flagship (the 'fake Moon') all along. The real Moon was hidden in a pocket dimension by the Anti-Spiral and later retrieved by Team Dai-Gurren.

The Anti-Spiral represents a philosophy of enforced stagnation, seeking to contain all Spiral life to prevent universal destruction.