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Frances Arnold

American chemical engineer and Nobel Laureate in Chemistry.

Frances Arnold

Frances Hamilton Arnold, born July 25, 1956, is an American chemical engineer who won the Nobel Prize in Chemistry in 2018 for inventing a method called directed evolution to create new enzymes. She holds the Linus Pauling Professorship of Chemical Engineering, Bioengineering and Biochemistry at Caltech. In 2019, she joined the board of Alphabet Inc., and during President Joe Biden’s term, she served as an external co-chair of his Council of Advisors on Science and Technology (PCAST).

Arnold grew up in the Pittsburgh area, the daughter of a nuclear physicist and a homemaker, with four brothers. As a teenager, she hitchhiked to Washington, D.C., to protest the Vietnam War, worked as a cocktail waitress and a cab driver, and lived independently. Her high school grades suffered from frequent absences, but she scored nearly perfectly on standardized tests and was admitted to Princeton University as a mechanical engineering major—she later said it was the easiest path into the school. She graduated in 1979 with a BS in mechanical and aerospace engineering, focusing on solar energy, and also studied economics, Russian, and Italian. After a year off to work in an Italian factory making nuclear reactor parts, she returned to Princeton and joined its Center for Energy and Environmental Studies. Following graduation, she worked as an engineer in South Korea and Brazil and at the Solar Energy Research Institute in Colorado, where she helped design solar facilities for remote locations and contributed to UN position papers.

She then earned a PhD in chemical engineering from UC Berkeley in 1985, despite having no prior chemistry background—her graduate committee required her to take undergraduate chemistry courses for her first year. Her thesis, in Harvey Warren Blanch’s lab, explored affinity chromatography. After a postdoc in biophysical chemistry at Berkeley, she joined Caltech as a visiting associate in 1986, became an assistant professor that same year, an associate professor in 1992, and a full professor in 1996. She was named the Dick and Barbara Dickinson Professor in 2000 and the Linus Pauling Professor in 2017. In 2013, she became director of Caltech’s Donna and Benjamin M. Rosen Bioengineering Center.

Quick Facts

Office
Co-Chair of the President's Council of Advisors on Science and Technology
Alongside
Maria Zuber and Francis Collins
President
Joe Biden
Term Start
January 20, 2021
Predecessor
Position established
Birth Name
Frances Hamilton Arnold
Birth Date
1956-07-25
Birth Place
Edgewood, Pennsylvania, U.S.
Spouse
Jay Bailey (1987–1991)
Partner
Andrew E. Lange (1994–2010)
Children
3
Education
Princeton University (BS) / University of California, Berkeley (MS, PhD)

Facts from the source article.

Lore & Background

Arnold is the daughter of Josephine Inman and nuclear physicist William Howard Arnold, and the granddaughter of Lieutenant General William Howard Arnold. She grew up in the Pittsburgh suburb of Edgewood and the Pittsburgh neighborhoods of Shadyside and Squirrel Hill, graduating from Taylor Allderdice High School in 1974. As a high schooler, she hitchhiked to Washington, D.C., to protest the Vietnam War and worked as a cocktail waitress and cab driver. Despite low grades due to absences, she made near perfect standardized test scores and was accepted to Princeton University as a mechanical engineering major. She graduated in 1979 with a BS in mechanical and aerospace engineering, focusing on solar energy research. She earned a PhD in chemical engineering from the University of California, Berkeley in 1985, despite having no chemistry background before her doctorate.

Reader's Guide

Frances Arnold is credited with pioneering the use of directed evolution to create enzymes with improved or novel functions. Her strategy involves iterative rounds of mutagenesis and screening for proteins with improved functions, accelerating a process that in nature occurs over long time periods. In her seminal 1993 work, she used directed evolution to engineer a version of subtilisin E active in the organic solvent DMF, achieving 256 times more activity than the original. This method has broad implications for producing renewable fuels, pharmaceutical compounds, and other useful biological systems. Arnold has co-founded companies including Gevo, Inc. and Provivi, and holds over 40 US patents. She has served on the board of Alphabet Inc. since 2019 and as an external co-chair of President Joe Biden's Council of Advisors on Science and Technology (PCAST) starting in January 2021, emphasizing the importance of reestablishing trust in science in policymaking.

Did You Know?

The Austrian Oak: A Bodybuilding Legacy

Schwarzenegger's journey into competitive bodybuilding began in 1960, when a football coach led his team to a local gym. By age 14 he had already committed to the sport as a lifelong pursuit, and by 20 he had claimed the Mr. Universe title. His dominance in the ring was extraordinary: seven Mr. Olympia victories placed him in a rare tier of achievement, sharing the second-highest win count with Phil Heath. Competitors and fans alike knew him as the "Austrian Oak," a moniker that captured both his physical presence and his Austrian roots. Beyond the stage, he contributed to the sport's literature with works like Arnold: The Education of a Bodybuilder (1977) and The New Encyclopedia of Modern Bodybuilding (1998). The Arnold Sports Festival, the second-largest bodybuilding competition after Mr. Olympia itself, bears his name as a testament to his lasting influence. His appearance in the 1977 documentary Pumping Iron not only captured a pivotal moment in bodybuilding history but also opened the door to his next chapter in entertainment.

From the Gym Floor to Global Stardom

Following his retirement from competitive bodybuilding, Schwarzenegger transformed into one of the most recognizable action stars of the 1980s. His breakthrough arrived with Conan the Barbarian in 1982, followed by the sequel Conan the Destroyer in 1984, but it was his portrayal of the Terminator in 1984 that cemented his global stardom—a role he would reprise in four additional sequels. His filmography spans a remarkable range of action and comedy, including Commando, The Running Man, Predator, Total Recall, and True Lies on the action side, alongside lighter fare like Twins, Kindergarten Cop, and Jingle All the Way. During the peak of his career, his rivalry with Sylvester Stallone became a defining feature of the era's action cinema. Collectively, the films in which he has appeared have generated more than $5.4 billion in worldwide box office revenue. He also founded Oak Productions, a film production company that afforded him greater creative control over the projects he undertook.

An Unconventional Path to the Governor's Office

Schwarzenegger's foray into politics began well before his governorship. As a registered Republican, he served as chair of the President's Council on Physical Fitness and Sports during much of the George H. W. Bush administration. His path to the California governor's mansion was anything but traditional: in 2003, he won a special recall election to replace incumbent Gray Davis, capturing 48.6 percent of the vote and finishing 17 points ahead of Democrat Cruz Bustamante. He was sworn in on November 17, 2003, to complete Davis's remaining term. Four years later, voters returned him to office with an even stronger mandate—55.9 percent in the 2006 gubernatorial race—granting him a full term. He served until reaching the constitutional term limit in 2011, after which he returned to acting. As of 2026, he and insurance commissioner Steve Poizner remain the last Republicans to win or hold statewide office in California, with Schwarzenegger standing as the state's most recent Republican governor.

A Strict Childhood in the Austrian Countryside

Born on July 30, 1947, in Thal, Styria, Schwarzenegger grew up as the second son of Gustav, a local police chief, and Aurelia, his younger wife. His father's wartime service—including combat in Poland, France, and the Soviet Union, and a later period as a price control official—drew significant media scrutiny during the 2003 recall campaign. The household was strict and Catholic; Schwarzenegger described a childhood marked by physical discipline, saying his hair was pulled and he was struck with belts. His father, who openly favored his elder son Meinhard, reportedly harbored an unfounded suspicion about Arnold's paternity. Despite these hardships, Schwarzenegger recalled a close bond with his mother, whom he maintained contact with until her death. Academically average but cheerful and exuberant in personality, he struggled with reading and was later diagnosed with dyslexia. Money was tight, and he remembered the family's purchase of a refrigerator as one of the highlights of his youth. It was this environment of constraint that, in his own words, forged his determination to leave, to become wealthy, and to become somebody.

Frequently Asked Questions

Who is Frances Arnold?

Frances Hamilton Arnold is an American scientist born in 1956 whose expertise spans chemical engineering, bioengineering, and biochemistry. She is best known for devising directed evolution, a technique that lets researchers design enzymes with brand-new functions.

What did Frances Arnold win the Nobel Prize for?

In 2018 she was awarded the Nobel Prize in Chemistry for creating directed evolution, a method that iteratively mutates and selects proteins so scientists can build enzymes that did not previously exist in nature.

Where does Frances Arnold hold her academic position?

She occupies the Linus Pauling Professorship of Chemical Engineering, Bioengineering, and Biochemistry at the California Institute of Technology (Caltech).

What government or industry roles has Frances Arnold held?

She joined Alphabet Inc.'s board of directors in 2019 and, during President Biden's administration, served as an external co-chair of the Council of Advisors on Science and Technology (PCAST).

What is Frances Arnold's background and upbringing?

Born on July 25, 1956, she grew up in the Pittsburgh area as one of five children, with a father who worked as a nuclear physicist and a mother who was a homemaker.

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