Toxic Effects of Substances Chiefly Nonmedicinal As to Source Codexery

Derived no-effect level

Exposure level above which humans must not be exposed.

The derived no-effect level, or DNEL, is the maximum exposure to a substance considered safe for humans. Under EU REACH rules, any manufacturer or importer handling 10 tonnes or more of a chemical per year must calculate DNELs as part of their safety assessment. These levels appear in the chemical safety report and the extended safety data sheet. The German Social Accident Insurance’s GESTIS DNEL list provides workplace DNELs for around 6,000 substances, with carcinogens clearly marked.

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EU REACH legislation

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