Mevastatin
First statin discovered, never marketed, derivatized to pravastatin.
Mevastatin, also known as compactin or ML-236B, is a hypolipidemic agent of the statin class. Isolated from Penicillium citrinum by Akira Endo in the 1970s, it was identified as an HMG-CoA reductase inhibitor. Although clinical trials were performed in Japan, it was never marketed. It has been derivatized to pravastatin.
Quick Facts
- Also known as
- compactin, ML-236B
- Class
- statin (HMG-CoA reductase inhibitor)
- Isolated by
- Akira Endo
- Derivative
- pravastatin
- Effect on melanoma cells
- high doses inhibit growth and proliferation
Facts from the source article.
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