Poisoning by Drugs, Medicaments and Biological Substances Codexery

Salicylate poisoning

Salicylate poisoning can cause tinnitus, metabolic acidosis, and cerebral edema.

Acute or chronic poisoning from a salicylate like aspirin is referred to as salicylate poisoning or aspirin poisoning.[1] Ringing ears, nausea, belly pain, and a rapid breathing rate constitute the typical symptoms.[1]

Quick Facts

Acute overdose mortality
about 1%
Lethal dose threshold
greater than 500 mg/kg
Toxic dose threshold
greater than 150 mg per kg of body mass
Chronic toxicity dose
100 mg/kg per day for two or more days

Facts from the source article.

Key facts and history

Initial treatment of an overdose involves resuscitation measures and gastric decontamination by administering activated charcoal.[2] Documentation of salicylate's toxic effects goes back to at least 1877.[3] The 1918 flu pandemic's high death toll may have been partly driven by aspirin poisoning, according to some analyses.[4] In the United States during 2004, over 20,000 cases and 43 fatalities from salicylate poisoning were recorded.[3]

For a given dose, older individuals face a greater toxicity risk.[3] Cardiopulmonary arrest, typically from pulmonary edema, is the leading cause of death after an aspirin overdose.[5] Tinnitus induced by salicylate can result from high doses of the drug.[6]

What the cited sources add

The Open Library edition record for ISBN 9780323354790 lists "Rosen's Emergency Medicine : Concepts and Clinical Practice" as a 2017 Elsevier publication of 2688 pages.[7] The Open Library edition record for ISBN 9780323028455 lists "Rosen's emergency medicine" as a 2006 Mosby/Elsevier publication of 3179 pages.[8] The Open Library edition record for ISBN 9781550092639 lists "Ototoxicity" as a 2004 BC Decker publication of 220 pages.[9]

References

  1. Wikipedia, "Salicylate poisoning" (CC BY-SA 4.0), which cites: O'Malley, "Emergency department management of the salicylate-poisoned patient.", Emergency Medicine Clinics of North America, May 2007, p. 333–46; abstract viii; O'Malley, "Emergency department management of the salicylate-poisoned patient.", Emergency Medicine Clinics of North America, May 2007, p. 333–46; abstract viii; O'Malley, "Emergency department management of the salicylate-poisoned patient.", Emergency Medicine Clinics of North America, May 2007, p. 333–46; abstract viii; Brenner, "Pharmacology E-Book: with STUDENT CONSULT en.wikipedia.org
  2. Wikipedia, "Salicylate poisoning" (CC BY-SA 4.0), which cites: Palmer, "Salicylate Toxicity", New England Journal of Medicine, 25 June 2020, p. 2544–2555; Palmer, "Salicylate Toxicity", New England Journal of Medicine, 25 June 2020, p. 2544–2555; "Position paper: gastric lavage", Journal of Toxicology: Clinical Toxicology, 2004, p. 933–43; "Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management", Clinical Toxicology, 2007, p. 95–131; Hillman, "Treatment of salicylate poisoning with repeated oral charcoal", British Medical Journal (Clinical Research Ed.), Nov en.wikipedia.org
  3. Wikipedia, "Salicylate poisoning" (CC BY-SA 4.0), which cites: Roland, "Ototoxicity", PMPH-USA, 2004, p. 28; O'Malley, "Emergency department management of the salicylate-poisoned patient.", Emergency Medicine Clinics of North America, May 2007, p. 333–46; abstract viii; "Assessment of Safety of aspirin and other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)", FDA, 2002; Roland, "Ototoxicity", PMPH-USA, 2004, p. 28 (we also read that source) en.wikipedia.org
  4. Wikipedia, "Salicylate poisoning" (CC BY-SA 4.0), which cites: Starko, "Salicylates and pandemic influenza mortality, 1918-1919 pharmacology, pathology, and historic evidence.", Clinical Infectious Diseases, 1 November 2009, p. 1405–10 (original not read by us) en.wikipedia.org
  5. Wikipedia, "Salicylate poisoning" (CC BY-SA 4.0), which cites: Thisted, "Acute salicylate self-poisoning in 177 consecutive patients treated in ICU", Acta Anaesthesiologica Scandinavica, May 1987, p. 312–6 (original not read by us) en.wikipedia.org
  6. Wikipedia, "Salicylate poisoning" (CC BY-SA 4.0), which cites: Stolzberg, "Salicylate toxicity model of tinnitus", Frontiers in Systems Neuroscience, 20 April 2012, p. 28 (original not read by us) en.wikipedia.org
  7. Open Library record, ISBN 9780323354790 ("Rosen's Emergency Medicine : Concepts and Clinical Practice"). CC0 (metadata); book content not read. openlibrary.org
  8. Open Library record, ISBN 9780323028455 ("Rosen's emergency medicine"). CC0 (metadata); book content not read. openlibrary.org
  9. Open Library record, ISBN 9781550092639 ("Ototoxicity"). CC0 (metadata); book content not read. openlibrary.org

Each numbered sentence above was checked against the source it cites before publication. Sentences citing Wikipedia adapt text from the English Wikipedia article Salicylate poisoning (contributors), used under CC BY-SA 4.0; this entry is available under the same licence. Other sources were used for facts only; no text or images are copied from them.

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