Receptor (biochemistry)
Proteins that bind ligands to trigger cellular responses.
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The location of receptor proteins, whether on the cell surface or inside the cell, provides a basis for their classification.[1]
Quick Facts
- Field
- Biochemistry and pharmacology
Facts from the source article.
Key facts and history
Ligand-gated ion channels are typically targets of fast neurotransmitters like acetylcholine and GABA.[2] G protein-coupled receptors are the largest family of receptors and include receptors for hormones like dopamine.[2] A receptor displaying constitutive activity produces a biological response without a bound ligand.[3] When GABA binds to its receptor, it reduces the electrical activity of neurons, functioning as an inhibitory neurotransmitter.[4]
Receptors situated inside the cell are divided into those found in the cytoplasm and those located in the nucleus.[1] A substance produced within the body that attaches to a specific receptor is called its endogenous ligand.[5]
What the research sources say
The Open Library record for "Rang Dales Pharmacology" (ISBN 9780702034718) was published by Churchill Livingstone in 2011.[6] The Open Library record for "Guyton and Hall Textbook of Medical Physiology" (ISBN 9781455770052) was published by Elsevier in 2015.[7] The Open Library record for "Medical Physiology, Updated Edition" (ISBN 1416023283) was published by Saunders in November 2004.[8]
References
- Wikipedia, "Receptor (biochemistry)" (CC BY-SA 4.0), which cites: Guyton, "Guyton and Hall Textbook of Medical Physiology", Elsevier Saunders, 2016, p. 930–937; Guyton, "Guyton and Hall Textbook of Medical Physiology", Elsevier Saunders, 2016, p. 930–937 (we also read that source) en.wikipedia.org
- Wikipedia, "Receptor (biochemistry)" (CC BY-SA 4.0), which cites: "The impact of GPCR structures on pharmacology and structure-based drug design", British Journal of Pharmacology, March 2010, p. 986–96; "Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers", Nature Chemical Biology, August 2011, p. 740–7 (original not read by us) en.wikipedia.org
- Wikipedia, "Receptor (biochemistry)" (CC BY-SA 4.0), which cites: "Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective", Molecular Pharmacology, December 2003, p. 1271–6 (original not read by us) en.wikipedia.org
- Wikipedia, "Receptor (biochemistry)" (CC BY-SA 4.0), which cites: Mihic, "GABA and the GABA Receptor", Alcohol Health and Research World, 1997, p. 127–131; Alberts, "Essential Cell Biology", Science, 2014, p. 534; Alberts, "Essential Cell Biology", Science, 2014, p. 534 (original not read by us) en.wikipedia.org
- Wikipedia, "Receptor (biochemistry)" (CC BY-SA 4.0), which cites: Gotti, "Nicotinic acetylcholine receptors (version 2019.4)", IUPHAR/BPS Guide to Pharmacology CITE, 16 September 2019; "Molecular Neuropharmacology: A Foundation for Clinical Neuroscience", McGraw-Hill Medical, 2009, p. 234; "Curare Drug Information, Professional", Drugs.com (original not read by us) en.wikipedia.org
- Open Library record, ISBN 9780702034718 ("Rang Dales Pharmacology"). CC0 (metadata); book content not read. openlibrary.org
- Open Library record, ISBN 9781455770052 ("Guyton and Hall Textbook of Medical Physiology (Guyton Physiology)"). CC0 (metadata); book content not read. openlibrary.org
- Open Library record, ISBN 1416023283 ("Medical Physiology, Updated Edition"). CC0 (metadata); book content not read. openlibrary.org
Each numbered sentence above was checked against the source it cites before publication. Sentences citing Wikipedia adapt text from the English Wikipedia article Receptor (biochemistry) (contributors), used under CC BY-SA 4.0; this entry is available under the same licence. Other sources were used for facts only; no text or images are copied from them.
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Sources
Compiled from Wikipedia and the sources listed below. Text from Wikipedia is available under CC BY-SA 4.0; this entry is adapted from it.
- Wikipedia: Receptor (biochemistry) (CC BY-SA 4.0).
- Word definitions: the , each quoted from its Wikipedia article.
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