HLA-B27
HLA-B27 is strongly linked to ankylosing spondylitis and related diseases.
It presents antigenic peptides derived from self and non-self antigens to T cells.[1] On chromosome 6, the B locus within the major histocompatibility complex encodes the class I surface molecule known as HLA-B27.[1] Most individuals who test positive for HLA-B27 will not go on to experience any related condition.[2]
Quick Facts
- Prevalence in united states
- 6-8%
- Prevalence in north africans
- 4%
- Prevalence in chinese
- 2–9%
- Prevalence in japanese descent
- 0.1–0.5%
- Prevalence in northern scandinavians
- 14-16%
- Prevalence in finland
- 14%
Facts from the source article.
Key facts and history
Among the Sami in Northern Scandinavia, 24% of people are HLA-B27 positive.[3] Because of its strong link to spondyloarthropathies, HLA-B27 has been studied more extensively than any other HLA-B allele.[4] In the United States, between 6% and 8% of people are estimated to carry HLA-B27.[3] In Finland, about 14% of the general population is HLA-B27 positive, and more than 95% of those with ankylosing spondylitis carry this marker.[3]
Among people with psoriatic arthritis, roughly 40% to 50% are HLA-B27 positive.[5] Conditions such as reactive arthritis, acute anterior uveitis, iritis, Crohn's disease, and ulcerative colitis associated spondyloarthritis are all linked to HLA-B27.[6] Because these diseases all share an association with HLA-B27, they tend to occur together more frequently.[6] HLA-B27 is found at a notably higher rate in HIV long-term nonprogressors.[7]
What the research sources say
The book "The Hla Complex In Biology And Medicine A Resource Book" was published by Jaypee Medical Publishers in 2010.[8] The book "Step-up to medicine" was published by Lippincott Williams & Wilkins in 2008.[9]
References
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: M. A. Khan, "The HLA Complex in Biology and Medicine", Jayppee Brothers Medical Publishers, 2010, p. 259–275 (we also read that source) en.wikipedia.org
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: Parameswaran, "StatPearls", StatPearls Publishing, November 30, 2024 (original not read by us) en.wikipedia.org
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: Parameswaran, "StatPearls", StatPearls Publishing, November 30, 2024; M. A. Khan, "The HLA Complex in Biology and Medicine", Jayppee Brothers Medical Publishers, 2010, p. 259–275; Johnsen, "The prevalence of ankylosing spondylitis among Norwegian Samis (Lapps)", The Journal of Rheumatology, October 1992, p. 1591–1594; Gran, "The Prevalence of HLA-B27 in Northern Norway", Scandinavian Journal of Rheumatology, January 1984, p. 173–176; Bjelle, "HLA B 27 in the Population of Northern Sweden", Scandinavian Journal of Rheumatology, January 1982, p. en.wikipedia.org
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: Hacquard-Bouder, "Animal models of HLA-B27-associated diseases: new outcomes", Joint Bone Spine, March 2006, p. 132–138 (original not read by us) en.wikipedia.org
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: Ritchlin, "Psoriatic Arthritis", New England Journal of Medicine, March 9, 2017, p. 957–970 (original not read by us) en.wikipedia.org
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: "Step-Up to Medicine (Step-Up Series)", Lippincott Williams & Wilkins, 2008; Kataria, "Spondyloarthropathies", American Family Physician, June 2004, p. 2853–2860 (we also read that source) en.wikipedia.org
- Wikipedia, "HLA-B27" (CC BY-SA 4.0), which cites: "HIV+ Long-Term Non-Progressor Study", National Institute of Allergy and Infectious Diseases, June 23, 2010; Deeks, "Human Immunodeficiency Virus Controllers: Mechanisms of Durable Virus Control in the Absence of Antiretroviral Therapy", Immunity, September 2007, p. 406–416 (original not read by us) en.wikipedia.org
- Open Library record, ISBN 9788184488708 ("The Hla Complex In Biology And Medicine A Resource Book"). CC0 (metadata); book content not read. openlibrary.org
- Open Library record, ISBN 9780781771535 ("Step-up to medicine"). CC0 (metadata); book content not read. openlibrary.org
Each numbered sentence above was checked against the source it cites before publication. Sentences citing Wikipedia adapt text from the English Wikipedia article HLA-B27 (contributors), used under CC BY-SA 4.0; this entry is available under the same licence. Other sources were used for facts only; no text or images are copied from them.
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