Africa/Harvard School of Public Health Partnership for Cohort Research and Training
Collaborative cohort study investigating chronic disease in sub-Saharan Africa.
The Africa/Harvard School of Public Health Partnership for Cohort Research and Training (Africa/HSPH PaCT) began in 2009. Principal investigators Dr. Hans-Olov Adami and Dr. Michelle D. Holmes lead the project, with project manager Dr. Todd G. Reid and research scientist Dr. Shona Dalal representing the Harvard Coordinating Site. This site collaborates with partner institutions in four countries: Nigeria, South Africa, Tanzania, and Uganda. The partnership aims to study how lifestyle factors relate to chronic disease risk across sub-Saharan Africa. To do this, it will conduct a large epidemiological cohort study involving roughly 500,000 participants. The project also intends to build research infrastructure and train a new wave of health professionals.
- known_for
- Large-scale cohort study in sub-Saharan Africa using mobile phone technology
- research_sites
- Nigeria (2 sites), South Africa, Tanzania, Uganda
Lore & Background
The Africa/HSPH PaCT project was launched in 2009 to address the rising pandemic of heart disease, mental illness, cancer, and diabetes in Africa. Dr. Michelle D. Holmes, who witnessed the beginning of the AIDS pandemic in 1980s New York City, serves as Co-Principal Investigator. The project plans to collect data on diet, exercise, smoking, and other habits from approximately 500,000 participants across four countries (with five sites), filling a critical gap in African health data. Pilot studies have been started in all five sites, enrolling about 1,500 participants followed for six months, with data collected via questionnaires, face-to-face interviews, and blood samples.
Reader's Guide
The Africa/HSPH PaCT represents a significant effort to generate evidence on chronic non-communicable diseases (NCDs) in sub-Saharan Africa, where such data have been lacking. By employing mobile phone technology for enrollment, retention, and follow-up, the project pioneers cost-effective methods for large-scale longitudinal studies in the region. The partnership also focuses on training a new generation of public health researchers and practitioners, and on spurring social entrepreneurship for chronic disease management. The project's collaboration with the MIT Human Dynamics Group and its participation in the World Cohort Integration Workshop highlight its role in fostering international data sharing and methodological innovation. Its findings are expected to guide prevention policies for NCDs in Africa.
Did You Know?
- The project plans to enroll approximately 500,000 participants from four countries (five sites) over a five-year period.
- Pilot studies enrolled about 1,500 participants across all five sites and followed them for six months.
- The project collaborates with the Human Dynamics Group of the Pentland Lab at MIT for mobile phone data analytics.
Origins & Institutional Evolution
The Harvard T.H. Chan School of Public Health did not appear fully formed. Its roots stretch back to 1913, when a joint venture between Harvard and MIT established the School for Health Officers—what Harvard itself describes as the country's first graduate-level training program focused on population health. For nearly a decade, this modest training ground operated under a shared identity before shedding its MIT connection in 1922 and rebranding as the Harvard School of Public Health. Even then, it remained tethered to Harvard Medical School, functioning as a subsidiary rather than an independent entity. Full autonomy arrived in 1946, when the school gained its own dedicated public health and medical faculty, finally standing as a separate institution within the Harvard ecosystem. That 1946 milestone marked the point at which the school could chart its own academic course, recruit its own leadership, and build the broad, multidisciplinary identity it carries today. The journey from a two-university training program to a standalone graduate school encapsulates a century of evolving American public health education.
The Chan Renaming & A Generous Legacy
In 2014, the school received a name that would anchor its modern identity. The Morningside Foundation, directed by Gerald Chan (a 1975 SM and 1979 SD graduate of the school) and his brother Ronnie Chan, pledged $350 million—the single largest gift in Harvard's history up to that point. The foundation was named for their father, Chan Tseng-hsi, a Hong Kong entrepreneur whose vision extended well beyond the business world. The renaming to the Harvard T.H. Chan School of Public Health was a public acknowledgment that the school's future was being shaped by its own alumni community. Gerald Chan's dual degree path through the institution—first a master's in public health, then a doctorate in science—illustrates the kind of deep institutional loyalty the gift represented. The donation did not merely buy a plaque; it signaled a commitment to sustaining the school's research infrastructure, its global programs, and its educational mission for generations of students yet to arrive.
Curriculum Architecture & the Degree Revolution
The school's academic structure reflects a deliberate philosophy: different career trajectories demand different training architectures. The Master of Public Health program spans ten distinct fields, from Epidemiology and Nutrition to Health Policy and Quantitative Methods, while the Master of Health Care Management targets future practitioners in professional settings. Master of Science degrees, by contrast, are calibrated for aspiring researchers, with credit requirements flexing based on whether a student arrives with a bachelor's, master's, or doctoral credential. In 2016, the school announced a sweeping consolidation: beginning in fall 2017, five separate Doctor of Science research programs—Epidemiology, Environmental Health, Global Health and Population, Nutrition, and Social and Behavioral Sciences—merged into a single Ph.D. in Population Health Sciences administered through the Graduate School of Arts and Sciences. Students already enrolled in the ScD tracks completed their studies as the final cohort of that 144-year-old degree, which had first been awarded in 1872. Simultaneously, the 2014 launch of the Doctor of Public Health introduced a three-year, cohort-based doctoral path blending advanced public health study with leadership, management, and innovation training, including a field-based doctoral project.
Research Legacy & Global Footprint
Few institutions can claim the kind of longitudinal research infrastructure the Harvard Chan School has built. The Nurses' Health Study and its successor, Nurses' Health Study II, have tracked the health of more than 100,000 women since 1976, generating findings that have fed into hundreds of published papers. The Health Professionals Follow-up Study mirrors that ambition for over 50,000 men, linking diet, exercise, smoking, and medication use to cancer and cardiovascular outcomes. Beyond these domestic cohorts, the International Health Systems Program has delivered training and technical assistance across 21 countries while conducting health policy research. The Program on the Global Demography of Aging zeroes in on the economics of aging in the developing world. The Lee Kum Sheung Center for Health and Happiness coordinates cross-disciplinary research into how positive psychological well-being intersects with physical health and longevity. The Health Systems Innovation Lab, led by Professor Rifat Atun, pursues comparative health systems research and works with governments, multilateral bodies, and civil society to accelerate the diffusion of high-value health system innovations at the population level.
Frequently Asked Questions
What is the Africa/Harvard School of Public Health Partnership for Cohort Research and Training (Africa/HSPH PaCT)?
Africa/HSPH PaCT is a collaborative epidemiology initiative launched in 2009 that brings together Harvard's School of Public Health and partner institutions across sub-Saharan Africa. Its central mission is to run a large-scale cohort study examining how everyday lifestyle choices influence the risk of chronic diseases in the region.
Who are the principal investigators and key staff behind Africa/HSPH PaCT?
The project is co-led by Dr. Hans-Olov Adami and Dr. Michelle D. Holmes as principal investigators. On the Harvard Coordinating Site side, Dr. Todd G. Reid serves as project manager and Dr. Shona Dalal works as the research scientist.
Which countries and sites are part of the Africa/HSPH PaCT study?
The partnership spans four sub-Saharan African nations: Nigeria (with two separate research sites), South Africa, Tanzania, and Uganda. Each country contributes local partner institutions that collaborate with Harvard on data collection and analysis.
What makes Africa/HSPH PaCT's methodology stand out from other cohort studies?
The project is notable for integrating mobile phone technology into its large-scale data-gathering framework, allowing researchers to track participant information across a geographically dispersed population. This approach is relatively uncommon in sub-Saharan African epidemiology and helps sustain long-term follow-up of a large cohort.
Why is Africa/HSPH PaCT considered important for public-health research?
It fills a critical gap by generating longitudinal, population-level evidence on chronic-disease risk factors specific to sub-Saharan African communities, where such data have historically been scarce. The partnership also doubles as a training platform, building local research capacity in the four partner countries.
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