Addermire Institute

A medical facility in Karnaca where science and the supernatural collide.

The Addermire Institute is a location in Dishonored 2, set in the fictional city of Karnaca. It is a medical facility that appears during the game's story, serving as a key mission area. The institute is known for its research into the plague and supernatural phenomena, and it is where the player encounters various enemies and environmental hazards. The building itself is a multi-story structure with laboratories, patient wards, and administrative offices, reflecting its function as a center for scientific study. The institute's design incorporates elements of Mediterranean architecture, consistent with the game's aesthetic inspired by countries like Greece, Italy, and Spain. The facility is powered by wind turbines, a common feature of Karnaca's infrastructure, and its interior is marked by dust and decay, indicative of the city's overall condition.

Quick Facts

Location: Karnaca
Notable residents: Dr. Alexandria Hypatia

Lore & Background

The Addermire Institute is located in Karnaca, the capital of Serkonos, a coastal city in the Empire of the Isles. The institute is dedicated to the study of diseases and supernatural afflictions, particularly the plague that has affected the region. It is run by Dr. Alexandria Hypatia, a respected physician who is later revealed to be the target of an assassination mission. The facility contains laboratories, patient rooms, and a morgue, and it is guarded by the Grand Serkonan Guard.

The institute's research includes experiments on bloodflies, which are insects that make nests in corpses and are a recurring hazard in the game. The player may explore the institute to gather information, find upgrades, and complete objectives related to the main storyline. The building's layout includes multiple floors and hidden areas, encouraging exploration and offering alternative paths for stealth or combat approaches.

Reader's Guide

When exploring the Addermire Institute, players should be prepared for a mix of stealth and combat encounters. The facility is patrolled by guards and contains bloodfly nests that spawn enemies if disturbed. Key areas include the main lobby, the patient wards, the morgue, and Dr. Hypatia's office. Players can find blueprints, runes, and bone charms throughout the building, which provide upgrades and passive benefits.

The mission's primary objective is to deal with Dr. Hypatia, who transforms into the Crown Killer when alerted. A non-lethal approach requires locating a serum formula in the laboratory and using it on Hypatia during the confrontation. The institute also features a Wall of Light barrier that can be disabled or rewired. Players should watch for environmental hazards like exploding whale oil canisters and use the game's supernatural abilities—such as Far Reach or Blink—to navigate vertical spaces and avoid detection.

The chaos system affects the number of enemies and the state of the environment, with higher chaos leading to more bloodflies and hostile NPCs.

Did You Know?

The Addermire Institute is named after Dr. Theodorus Addermire, a character from the first Dishonored game, but in Dishonored 2 it is run by Dr. Alexandria Hypatia.
Dr. Hypatia is voiced by actress Rosario Dawson, who also voices other characters in the game.
The institute's morgue contains the bodies of victims killed by the Crown Killer, a persona that Hypatia adopts under the influence of a supernatural affliction.
The building's architecture reflects the Mediterranean influences of Karnaca, with white stone walls and red-tiled roofs.

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