Rheumatoid nodulosis
A rheumatoid arthritis variant with multiple subcutaneous nodules.
Rheumatoid nodulosis is a cutaneous condition linked to rheumatoid arthritis. It is notable for the appearance of multiple nodules, most often on the hands.
Quick Facts
- Synonym
- Accelerated rheumatoid nodulosis
- Specialty
- Dermatology
Facts from the source article.
Did You Know?
- Rheumatoid nodules are linked to more severe erosive disease in patients with rheumatoid arthritis.
- The nodules can occur anywhere on the body, not just on extensor surfaces.
- Palindromic rheumatism is associated with rheumatoid nodulosis without loss of joint function.
Mechanism
Numerous theories exist regarding the pathophysiology of nodules linked to rheumatoid arthritis, none entirely accepted. One hypothesis suggests minor local trauma to small blood vessels causes pooling of rheumatoid factor-containing immune complexes. These complexes may activate macrophages, releasing chemotactic factors that draw in more macrophages, ultimately forming granulomas with central necrosis. Other theories propose roles for underlying vasculitis or genetic factors.
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